Cytotoxic Drug Safety Cabinets

CCL Presents the  CG2010 Cytogard Cytotoxic Safety Cabinet


Cytotoxic drug safety cabinets are defined in Australian Standard AS2252.5 as the primary barrier against exposure to aerosols that are produced in the preparation, manipulation and dispensing of cytotoxic drugs. Many of these drugs are known to be mutagens and are suspected of being carcinogens and teratogens. Recent work involving prions has proven that exposure may result in effects that are insidious and may not manifest themselves for some years. The requirements for protection involve the following:

  •  Protection of cabinet users and other staff from exposure to aerosols or vapours which may be generated in the preparation, manipulation, and dispensing of cytotoxic drugs;
  •  Protection of drug products, so that they may be prepared in an environment which is essentially free from particulate and biological contamination;
  •  Protection of cabinet maintenance personnel from the residue of drug particles which can contaminate filters, fans and other mechanical components.


CG2010 CytogardTM drug cabinets are designed and manufactured in Australia in three nominal widths – a 900mm, 1200mm and 1800mm – and fully comply with all requirements of Australian Standard AS2252.5.

Cytotoxic cabinets are necessary for operator and product protection, in addition to the safe guards provided by an effective air barrier and Clyde-Apac MicrosealTM HEPA filter technology, CG2010 series is also equipped with a carbon filter to remove harmful vapours that may be released during the compounding process. CG2010 series are essential for the protection of personnel, product and the environment.

Australian Standards

CG2010 CytogardTM drug safety cabinets are designed and manufactured to comply with all requirements of Australian Standard AS2252.5.

Each cabinet is factory-certified by a NATA Accredited laboratory to meet the specified performance requirements. These cabinets may also be used where the handling of other drugs and chemical requires both containment and aseptic manipulation.

Cytotoxic safety cabinets are part- recirculating laminar air flow enclosures with high efficiency particulate air (HEPA) filtration of exhaust air and an air barrier at the work opening.

HEPA-filtered vertical laminar airflow which is recirculated in the work zone creates an ultra-clean work environment for product protection. An air barrier between the operator and the work zone is maintained by a flow of room air into a full width grille in the work opening.

The barrier air mixes with the recirculated laminar flow air in a sump underneath the work surface and is exhausted from the cabinet via a HEPA filter which is located directly under the work tray.

All positive pressure zones and filter seals are surrounded by negative pressure zones, so as to contain potentially hazardous aerosols. Cabinets are available with the work zone width of 90cm, 120cm or 180cm and are free standing units that incorporate a floor stand.

Standard cabinets have exhaust discharge on the right-hand side with optional left-hand side or top exhaust available. Top exhaust is typically specified where cabinet exhaust air is to be entrained into the room exhaust in accordance with AS2252.5.

These cabinets provide advanced system monitoring technology and a number of unique design features intended to enhance safety and ease of use.




Constructed in electro-galvanised steel with joints welded using a gas shielded arc process. This method produces a robust, leak free housing that is able to withstand the rigours of transport and handling. The exterior is finished in a high- quality powder coat which has been developed for laboratory equipment.

Work Zone

Constructed in grade 304 stainless steel with 2B finish. Corners are radiused and crevice- free for ease of cleaning and all surfaces are carefully dressed to remove sharp edges. The removable work tray is designed to allow cleaning access to its underside without removing it from the cabinet.

A pneumatic mechanism opens and closes the viewing window without the need for external fasteners or catches. The window is self- supporting in the fully open position to facilitate cleaning and access for large items. Opening the window with the cabinet running automatically engages a boost mode for enhanced containment by activating a maximum exhaust airflow and the alarm systems.

Hepa Filters

Clyde Apac MicrosealTM HEPA filters, are manufactured to meet requirements of AS4260. Each filter is individually certified to be leak free in accordance with AS 1807.6.
A manufacturer endorsed test label fitted with an extract of the test report is affixed to each filter.

A prefilter extends the life of the exhaust HEPA filter and protects it from mechanical damage during cleaning of the work zone.


Separate direct drive fans are provided for the exhaust and laminar flow HEPA filters. Fans are fitted with speed controllers to enable airflows to be maintained through filter life.

The fan control circuits are interlocked so that the laminar flow system will not operate until the exhaust system has achieved a containment condition.

Audible and visible alarms with rechargeable battery back-up signify any reduction in barrier containment or laminar airflow.


Cabinets operate on single-phase 240V, 50 Hz power via a 10A outlet. The electrical system complies with Australian Standard AS3100.

A low voltage touch control panel is located on the front of the cabinet. The Optima 2000TM microprocessor-controlled control and diagnostic system provides continuous monitoring of critical cabinet functions with a digital display indicating the nature of any malfunction.


High-efficiency filters and fans deliver quiet operation and safety. Negative pressure zones surround all positive pressure areas, eliminating the possibility of contaminated air bypassing the filter or escaping from the cabinet. 

In operation, vertical laminar airflow gently passes from the Laminar HEPA filter to the sump HEPA filter to create a biologically clean work area.

In Cytotoxic cabinets: 

An air barrier across the work access opening, into the sump, reduces potential risks to personnel from airborne contaminants in the work zone. 

In Cytotoxic models, the airflows combine in the sump area beneath the work floor and pass through an extra HEPA filter before recirculation via a return air plenum, to the top housing.

Separate fan/filter arrangements allow independent adjustment to maintain an effective air barrier. 

A microprocessor is used to control the speed of the blower motors. This microprocessor also allows fingertip control of functions and status including:

  • Cabinet performance and status clearly displayed in plain English.
  • Boost mode.
  • Built-in stopwatch.